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REPORT OF THE TREATMENT OF EXPERIMENTAL FAT EMBOLISM WITH HEPARIN

A. M. N. Gardner 1; and M. H. M. Harrison 2

1 Division of Surgery, Radcliffe Infirmary, Oxford
2 The Nuffield Orthopaedic Centre, Oxford

1. Reports of the lipaemia-clearing effect of heparin suggested that this drug might be of therapeutic value in fat embolism.

2. In an experimental trial with rats, heparin was found both to accelerate death and to increase the number of deaths after fat embolism.

3. It is accordingly concluded that a clinical trial of heparin in human fat embolism would not be warranted.
(c) British Editorial Society of Bone and Joint Surgery All Rights Reserved
Registered charity no: 209299     Print ISSN: 0301-620X
Hip, Knee, Trauma, Upper limb, Foot & Ankle, Paediatrics, Oncology, Spine, Arthroplasty, General