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ENZYME ACTIVITY IN ARTICULAR CARTILAGE AFTER SYNOVECTOMY OF THE KNEE IN THE RABBIT

Robert D. Galway 1; and Richard L. Cruess 1

1 Orthopaedic Research Laboratories, Royal Victoria Hospital and McGill University, Montreal, Canada

Subtotal synovectomy was performed in the knee joints of New Zealand white rabbits. The changes noted in the articular cartilage as manifest by decreased metachromatic staining of the matrix were considered to indicate matrix degradation caused by the altered joint environment. The documentation of the enzyme changes suggests that the histological alteration in the articular cartilage noted after synovectomy may be mediated through the activation of endogenous chondrocyte lysozomal enzymes, particularly cathepsin and acid hydrolases.
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Hip, Knee, Trauma, Upper limb, Foot & Ankle, Paediatrics, Oncology, Spine, Arthroplasty, General