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CHONDROCYTE MULTIPLICATION IN OSTEOARTHRITIC ARTICULAR CARTILAGE

Alastair G. Rothwell 1; and George Bentley 1

1 Nuffield Orthopaedic Centre, Oxford; England

1. Twelve trephine specimens of articular cartilage and subchondral bone taken from six fresh osteoarthritic femoral heads were incubated in a medium containing tritiated thymidine, and autoradiographs were prepared from serial sections five microns thick.

2. Scattered labelling of chondrocytes in sections from four of the six femoral heads was demonstrated. No more than four labelled cells were seen in any one section. About half were found in typical chondrocyte clusters.

3. The implications of this evidence of chondrocyte multiplication with regard to the repair of damaged articular cartilage are discussed.
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Hip, Knee, Trauma, Upper limb, Foot & Ankle, Paediatrics, Oncology, Spine, Arthroplasty, General