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Journal of Bone and Joint Surgery - British Volume, Vol 60-B, Issue 4, 575-578
Copyright © 1978 by British Editorial Society of Bone and Joint Surgery

Articles

The effects of varying oxygen tensions upon bone resorption in vitro

DH Gray, JM Katz, and K Speak

Calvaria from six-day-old infant mice were grown on a grid culture in a chemically defined medium under varying oxygen tensions. Quantitative isotope studies demonstrated a linear association between bone resorption and oxygen tension in the physiological range. This result was supported by histological, histochemical and vital staining experiments. The clinical finding of osteoporosis in areas of hyperaemia could therefore be attributed to a rise in oxygen tension causing increased bone resorption.




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Hip, Knee, Trauma, Upper limb, Foot & Ankle, Paediatrics, Oncology, Spine, Arthroplasty, General