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Journal of Bone and Joint Surgery - British Volume, Vol 71-B, Issue 2, 205-208
Copyright © 1989 by British Editorial Society of Bone and Joint Surgery

Articles

The femoral head in osteonecrosis. A quantitative study of osteocyte population

S Humphreys, JD Spencer, Tighe JR, and RR Cumming

Department of Morbid Anatomy, King's College Hospital, London, England.

The occurrence of osteonecrosis following renal transplantation is well recognised but its pathogenesis remains unknown. We have quantified the number of empty osteocytic lacunae in the subchondral bone of femoral heads from a control group of patients, and compared these with femoral heads from a group of renal transplant recipients without evidence of overt osteonecrosis. There is a significant increase in empty osteocytic lacunae in renal transplant patients. We conclude that loss of osteocytes precedes other manifestations of osteonecrosis.


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J. D. Calder, A. L. Hine, M. F. Pearse, and P. A. Revell
The relationship between osteonecrosis of the proximal femur identified by MRI and lesions proven by histological examination
J Bone Joint Surg Br, February 1, 2008; 90-B(2): 154 - 158.
[Abstract] [Full Text] [PDF]


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