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Journal of Bone and Joint Surgery - British Volume, Vol 71-B, Issue 4, 632-637
Copyright © 1989 by British Editorial Society of Bone and Joint Surgery

Articles

The influence of the surface energy and roughness of implants on bone resorption

DW Murray, T Rae, and N Rushton

Orthopaedic Research Unit, University of Cambridge, Addenbrooke's Hospital, England.

We investigated the possibility that the macrophages which are seen around implants may stimulate bone resorption and cause loosening. We found that macrophages release mediators that stimulate bone resorption, and that the amount of resorption increased by between 2.5 and 10 times when the macrophages adhered to a foreign surface. This bone resorption depended on the surface energy and roughness of the foreign surface, varying with these physical properties rather than with the chemical nature of the material. It is concluded that loosening of orthopaedic implants is likely to be influenced by the surface energy and roughness of the implant.




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Hip, Knee, Trauma, Upper limb, Foot & Ankle, Paediatrics, Oncology, Spine, Arthroplasty, General