INFLUENCE OF LOCAL RECURRENCE ON THE PROGNOSIS OF SOFT-TISSUE SARCOMAST. Ueda, MD, Musculoskeletal Tumour Surgeon; H. Yoshikawa, MD, Chief of Musculoskeletal Tumour Surgery; and S. Mori, MD, Musculoskeletal Tumour SurgeonDepartment of Orthopaedic Surgery, Osaka Medical Centre for Cancer and Cardiovascular Diseases, 1-3-3 Nakamichi, Higashinari-ku, Osaka 537, Japan. N. Araki, MD, Musculoskeletal Tumour Surgeon; A. Myoui, MD, Musculoskeletal Tumour Surgeon; S. Kuratsu, MD, Musculoskeletal Tumour Surgeon; and A. Uchida, MD, Musculoskeletal Tumour Surgeon Department of Orthopaedic Surgery, Osaka University Medical School, 2-2 Yamadaoka, Suita 565, Japan. Correspondence should be sent to Dr T. Ueda. We have investigated the significance of local recurrence on survival in 173 patients with localised soft-tissue sarcomas of the limbs and of the trunk. The overall survival rates at five and ten years were 75.2% and 68.0%, respectively. After definitive surgery at our hospitals, there was local recurrence in 25 patients (14.5%). After inadequate operations elsewhere, there was a higher incidence of late local recurrence (28.3%), in comparison with those with primary tumours treated by us (9.0%), or patients referred to us immediately after inadequate surgery elsewhere (10.2%). Because of small numbers these differences in the survival rates were not statistically significantly different. Univariate survival analysis showed that local recurrence after definitive surgery (p = 0.006) together with the histological grade (p = 0.0002), the size of the tumour (p = 0.002), its depth in relation to deep fascia (p = 0.003), and the surgical margin (p = 0.0001) were the significant prognostic factors. Local recurrence at the initial presentation did not affect survival. Multivariate analysis showed that local recurrence after definitive surgery also lost its apparent prognostic significance. This article has been cited by other articles:
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