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INCOMPLETE HEALING OF SIMPLE BONE CYSTS AFTER STEROID INJECTIONS

A. Hashemi-Nejad, FRCS Orth, Clinical Orthopaedic Fellow; and W. G. Cole, PhD, FRCS C, Professor of Surgery and Head of Orthopaedics

Division of Orthopaedics, The Hospital for Sick Children, 555 University Avenue, Toronto, Ontario, Canada M5G 1X8.

Correspondence should be sent to Professor W. G. Cole.

We reviewed 32 children after the treatment of simple bone cysts by intralesional injections of methyl-prednisolone acetate. The age of the child and the activity and size of the cyst did not significantly affect the radiological outcome. The earliest time at which the radiological response could be reliably determined was three months. After a median period of review of five years, four (13%) cysts had healed, 20 (62%) cysts were partially visible but sclerotic, four (12.5%) were still visible but opaque and four (12.5%) were clearly visible. The healed and partially visible but sclerotic cysts were classified as having satisfactory radiological healing. This was observed in 13 of 32 cysts (41%) after the first injection, in eight of 21 (38%) after the second injection, but in relatively few of the remaining cysts after subsequent injections.

A satisfactory symptomatic outcome was achieved in all of the 18 children with humeral cysts and in the one child with a fibular cyst irrespective of the radiological outcome, but only in nine (67%) of the 13 children with femoral or tibial lesions, in whom the cysts were healed or sclerotic. The remaining four children had exertional bone pain and repeated fractures of their femoral or tibial cysts which were incompletely healed with sclerosis in one and opacities in three.

We conclude that the healing response to intralesional corticosteroids is unpredictable and usually incomplete even after multiple injections. The failure rate in weight-bearing bones is too high.




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H. S. Cho, J. H. Oh, H.-S. Kim, H. G. Kang, and S. H. Lee
Unicameral bone cysts: A COMPARISON OF INJECTION OF STEROID AND GRAFTING WITH AUTOLOGOUS BONE MARROW
J Bone Joint Surg Br, February 1, 2007; 89-B(2): 222 - 226.
[Abstract] [Full Text] [PDF]



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