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Influence of extracorporeal irradiation on the reintegration of autologous grafts of bone and joint

STUDY IN A CANINE MODEL

D. Sabo, MD, Assistant Professor1; D. R. C. Brocai, PhD1; M. Eble, MD, Assistant Professor2; M. Wannenmacher, MD, Professor and Chairman2; and V. Ewerbeck, MD, Professor and Chairman1

1 Department of Orthopaedic Surgery, University of Heidelberg, Schlierbacher Landstrasse 200 a, D-69118 Heidelberg, Germany.
2 Department of Radiotherapy, University of Heidelberg, Im Neuenheimer Feld 400, 69120 Heidelberg, Germany.

Correspondence should be sent to Dr D. Sabo.

We studied the effects of irradiation on the reintegration of autologous osteoarticular grafts over a period of 24 weeks in a canine model. In 16 foxhounds the medial femoral condyle was resected, irradiated and immediately replanted. In the control group resection and replantation were performed without irradiation. Reintegration was assessed by macroscopic analysis, histology, radiography and gait analysis.

Reintegration was equal at 12 weeks, but significantly inferior in the irradiated group after 24 weeks with delayed bone remodelling. The articular cartilage showed modest degeneration. Conventional radiography and histology showed corresponding changes. Limb function was adequate but the gait was inferior in the treated group.




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Hip, Knee, Trauma, Upper limb, Foot & Ankle, Paediatrics, Oncology, Spine, Arthroplasty, General