Logo of The Journal of Bone & Joint Surgery (Br)
Quick search:        
          Advanced Search
Guest Access | Sign In
This Article
Right arrow Full Text (PDF)
Right arrow Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow My Folders
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Ferrier, G. M.
Right arrow Articles by Andrew, J. G.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Ferrier, G. M.
Right arrow Articles by Andrew, J. G.

The effect of cyclic pressure on human monocyte-derived macrophages in vitro

G. M. Ferrier, FRCS, Clinical Lecturer in Orthopaedic Surgery; A. McEvoy, FRCS, Clinical Lecturer in Orthopaedic Surgery; C. E. Evans, PhD, Non-Clinical Lecturer in Orthopaedic Surgery; and J. G. Andrew, FRCS, Senior Lecturer in Orthopaedic Surgery

University of Manchester Musculoskeletal Research Group, Clinical Sciences Building, Hope Hospital, Stott Lane, Salford M6 8HD, UK.

Correspondence should be sent to Mr J. G. Andrew.

Aseptic loosening and osteolysis around prosthetic joints are the principal causes of failure and consequent revision. During this process activated macrophages produce cytokines which are thought to promote osteolysis by osteoclasts. Changes in pressure within the space around implants have been proposed as a cause of loosening and osteolysis. We therefore studied the effect of two different regimes of cyclic pressure on the production of interleukin-1ß (IL-1ß), IL-6 and tumour necrosis factor-{alpha} (TNF-{alpha}) by cultured human monocyte-derived (M-D) macrophages. There was a wide variation in the expression of cytokines in non-stimulated M-D macrophages from different donors and therefore cells from the same donor were compared under control and pressurised conditions.

Both regimes of cyclic pressure were found to increase expression of IL-6 and TNF-{alpha}. Expression of IL-1ß was increased by a higher-frequency regime only. Our findings suggest that M-D macrophages are activated by cyclic pressure. Further work will be required to understand the relative roles of frequency, amplitude and duration of applied pressure in the cellular effects of cyclic pressure in this system.




This article has been cited by other articles:


Home page
 J Bone Joint Surg BrHome page
L. Savarino, D. Granchi, E. Cenni, N. Baldini, M. Greco, and A. Giunti
Systemic cross-linked N-terminal telopeptide and procollagen I C-terminal extension peptide as markers of bone turnover after total hip arthroplasty
J Bone Joint Surg Br, April 1, 2005; 87-B(4): 571 - 576.
[Abstract] [Full Text] [PDF]

Home page
 BloodHome page
C. Brownstein, A. B. Deora, A. T. Jacovina, R. Weintraub, M. Gertler, K. M. F. Khan, D. J. Falcone, and K. A. Hajjar
Annexin II mediates plasminogen-dependent matrix invasion by human monocytes: enhanced expression by macrophages
Blood, January 1, 2004; 103(1): 317 - 324.
[Abstract] [Full Text] [PDF]


(c) British Editorial Society of Bone and Joint Surgery All Rights Reserved
Registered charity no: 209299     Print ISSN: 0301-620X
Hip, Knee, Trauma, Upper limb, Foot & Ankle, Paediatrics, Oncology, Spine, Arthroplasty, General