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Adverse tissue reactions to wear particles from Co-alloy articulations, increased by alumina-blasting particle contamination from cementless Ti-based total hip implants

A REPORT OF SEVEN REVISIONS WITH EARLY FAILURE

¹ Bone and Biomaterials Research, Institute of Histology and Embryology, University of Vienna, A-1090 Vienna, Austria.
² Institute of Social Medicine, University of Vienna, A-1080 Vienna, Austria.
³ Institute for Analytical Chemistry, University of Vienna, A-1090 Vienna, Austria.
⁴ Implant Testing Laboratory for Biomechanics and Experimental Orthopaedics, State Orthopaedic Clinic, D-81650 Munich, Germany.
⁵ Orthopaedic Hospital Speising, A-1134 Vienna, Austria.

Correspondence should be sent to Dr M. Böhler.

We revised seven alumina-blasted cementless hip prostheses (Ti-alloy stems, cp Ti threaded sockets) with low- or high-carbon Co-alloy bearings at a mean of 20.1 months after implantation because of pain and loosening. Histological examination of the retrieved periprosthetic tissues from two cases in which the implant was stable and three in which the socket was loose showed macrophages with basophilic granules containing metal and alumina wear particles and lymph-cell infiltrates. In one of the two cases of stem loosening the thickened neocapsule also contained definite lymphatic follicles and gross lymphocyte/plasma-cell infiltrates. Spectrometric determination of the concentration of elements in periprosthetic tissues from six cases was compared with that of joint capsules from five control patients undergoing primary hip surgery. In the revisions the mean concentration of implant-relevant elements was 693.85 µg/g dry tissue. In addition to Cr (15.2%), Co (4.3%), and Ti (10.3%), Al was predominant (68.1%) and all concentrations were significantly higher (p < 0.001) than those in the control tissues. The annual rates of linear wear were calculated for six implants. The mean value was 11.1 µm (heads 6.25 µm, inserts 4.82 µm). SEM/EDXA showed numerous fine scratches and deep furrows containing alumina particles in loosened sockets, and stems showed contamination with adhering or impacted alumina particles of between 2 and 50 µm in size.

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