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Journal of Bone and Joint Surgery - British Volume, Vol 84-B, Issue 4, 497-503.
doi: 10.1302/0301-620X.84B4.12434  
Copyright © 2002 by British Editorial Society of Bone and Joint Surgery
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Positive effects of anabolic steroids, vitamin D and calcium on muscle mass, bone mineral density and clinical function after a hip fracture

A RANDOMISED STUDY OF 63 WOMEN

M. Hedström, MD, Consultant Orthopaedic Surgeon; K. Åström, MD, Orthopaedic Surgeon; H. Sjöberg, MD, PhD; and N. Dalén, MD, PhD, Professor

Department of Orthopaedics

K. Sjöberg, MD, Consultant in Geriatrics

Danderyd Geriatric Clinic NLPO

E. Brosjö, MD, Consultant Radiologist

Division of Radiology
Karolinska Institute, Danderyd Hospital, 182 88 Danderyd, Sweden.

Correspondence should be sent to Dr M. Hedström.

A total of 63 women who had an operation for a fracture of the hip was randomly allocated to one year of treatment either with anabolic steroids, vitamin D and calcium (anabolic group) or with calcium only (control group). The thigh muscle volume was measured by quantitative CT. The bone mineral density of the hip, femur and tibia was assessed by quantitative CT and dual-energy x-ray absorptiometry and of the heel by quantitative ultrasound.

Quantitative CT showed that the anabolic group did not lose muscle volume during the first 12 months whereas the control group did (p<0.01). There was less bone loss in the proximal tibia in the anabolic group than in the control group. The speed of gait and the Harris hip score were significantly better in the anabolic group after six and 12 months.

Anabolic steroids, even in this moderate dose, given in combination with vitamin D and calcium had a beneficial effect on muscle volume, bone mineral density and clinical function in this group of elderly women.




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[Abstract] [Full Text] [PDF]


(c) British Editorial Society of Bone and Joint Surgery All Rights Reserved
Registered charity no: 209299     Print ISSN: 0301-620X
Hip, Knee, Trauma, Upper limb, Foot & Ankle, Paediatrics, Oncology, Spine, Arthroplasty, General