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Journal of Bone and Joint Surgery - British Volume, Vol 84-B, Issue 4,
571-578.
doi: 10.1302/0301-620X.84B4.11947 Copyright © 2002 by British Editorial Society of Bone and Joint Surgery Transplantation of cartilage-like tissue made by tissue engineering in the treatment of cartilage defects of the kneeM. Ochi, MD, PhD, Professor and Chairman1; Y. Uchio, MD, PhD, Assistant Professor1; K. Kawasaki, MD, Postgraduate1; S. Wakitani, MD, PhD2; and J. Iwasa, MD, Postgraduate1
1 Department of Orthopaedics, Shimane Medical University, 89-1 Enya-cho, Izumo-shi, Shimane-ken 693–8501, Japan. Correspondence should be sent to Professor M. Ochi. We investigated the clinical, arthroscopic and biomechanical outcome of transplanting autologous chondrocytes, cultured in atelocollagen gel, for the treatment of full-thickness defects of cartilage in 28 knees (26 patients) over a minimum period of 25 months. Transplantation eliminated locking of the knee and reduced pain and swelling in all patients. The mean Lysholm score improved significantly. Arthroscopic assessment indicated that 26 knees (93%) had a good or excellent outcome. There were few adverse features, except for marked hypertrophy of the graft in three knees, partial detachment of the periosteum in three and partial ossification of the graft in one. Biomechanical tests revealed that the transplants had acquired a hardness similar to that of the surrounding cartilage. We conclude that transplanting chondrocytes in a newly-formed matrix of atelocollagen gel can promote restoration of the articular cartilage of the knee. This article has been cited by other articles:
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