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Journal of Bone and Joint Surgery - British Volume, Vol 84-B, Issue 5, 706-711.
doi: 10.1302/0301-620X.84B5.12512  
Copyright © 2002 by British Editorial Society of Bone and Joint Surgery
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Stage-IIB osteosarcomas around the knee

A STUDY OF MMP-9 IN SURVIVING TUMOUR CELLS

A. F. Foukas, FRCS, Specialist Orthopaedic Registrar1; N. S. Deshmukh, FRCPath, Consultant Histopathologist2; R. J. Grimer, FRCS, Consultant Orthopaedic Surgeon2; D. C. Mangham, FRCPath, Consultant Histopathologist2; E. G. Mangos, MB ChB, Basic Surgical Trainee1; and S. Taylor, BSc, MSc, Medical Statistician3

1 Royal Liverpool University Hospital, Prescot Street, Liverpool L7 8XP, UK.
2 Royal Orthopaedic Hospital Birmingham, Bristol Road South, Northfield, Birmingham B31 2AP, UK.
3 Department of Mathematical Sciences, University of Liverpool, Peach Street, Liverpool L69 7ZL, UK.

Correspondence should be sent to Mr A. F. Foukas at 260 South Ferry Quay, Liverpool L3 4EJ, UK.

We studied 55 patients with stage-IIB osteosarcoma around the knee with respect to the expression of matrix metalloproteinase (MMP)-9 in the surviving tumour cells in surgical resection specimens. They were followed up for a minimum of 2.5 years.

Factors significantly associated with poor overall survival were a high serum level of alkaline phosphatase at diagnosis and tumour cells expressing MMP-9 in the resection specimens. The only factor strongly associated with disease-free survival was the immunohistochemical status of tumour cells for MMP-9 in the resection specimens. The percentage of necrosis after chemotherapy failed marginally to reach statistical significance. On Cox regression analysis only MMP-9 remained significant for overall and disease-free survival.






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Hip, Knee, Trauma, Upper limb, Foot & Ankle, Paediatrics, Oncology, Spine, Arthroplasty, General