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Journal of Bone and Joint Surgery - British Volume, Vol 84-B, Issue 6, 920-930.
doi: 10.1302/0301-620X.84B6.12457  
Copyright © 2002 by British Editorial Society of Bone and Joint Surgery
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Effects of alumina and zirconium dioxide particles on arachidonic acid metabolism and proinflammatory interleukin production in osteoarthritis and rheumatoid synovial cells

B. Liagre, PhD, Assistant Professor1; S. Moalic, PhD1; P. Vergne, PhD, MD2; J. L. Charissoux, PhD, MD3; D. Bernache-Assollant, PhD, Professor of Physics4; and J. L. Beneytout, PhD, Professor of Biochemistry1

1 Laboratoire de Biochimie, UPRES EA 1085, Faculté de Pharmacie, 2 rue du Docteur Marchland, 87025 Limoges Cedex, France.
2 Service de Rhumatologie
3 Service d’Orthopédie-Traumatologie, CHRU de Limoges, Hôpital Dupuytren, 2 Avenue Martin Luther King, 87042 Limoges Cedex, France.
4 UMR CNRS 6638 Science des Procédés Céramiques et Traitements de Surface, Faculté des Sciences, 123 Avenue Albert-Thomas, 87060 Limoges Cedex, France.

Correspondence should be sent to Dr J. L. Charissoux.

We describe a model which can be used for in vitro biocompatibility assays of biomaterials.

We studied the in vitro response of human osteoarthritis or rheumatoid arthritis fibroblast-like synoviocytes to Al2O3 or ZrO2 particles by analyzing the production of interleukin-1 (IL-1) and interleukin-6 (IL-6) and the metabolism of arachidonic acid via lipoxygenase and cyclo-oxygenase pathways.

Our results show that, in these cells and under our experimental conditions, Al2O3 and ZrO2 did not significantly modify the synthesis of IL-1 and IL-6 or the metabolism of arachidonic acid.






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Hip, Knee, Trauma, Upper limb, Foot & Ankle, Paediatrics, Oncology, Spine, Arthroplasty, General