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Journal of Bone and Joint Surgery - British Volume, Vol 84-B, Issue 8,
1156-1161.
doi: 10.1302/0301-620X.84B8.13508 Copyright © 2002 by British Editorial Society of Bone and Joint Surgery Treatment of malignant bone tumours by extracorporeally irradiated autograft-prosthetic composite arthroplastyW. M. Chen, MD, Chief of Division; T. H. Chen, MD, Chairman of Department; C. K. Huang, MD, Attending Surgeon; C. C. Chiang, MD, Attending Surgeon; and W. H. Lo, MD, Consultant Orthopaedic Surgeon
Department of Orthopaedics and Traumatology, Veterans General Hospital, 201, Sec. 2, Shih-Pai Road, Taipei 112, Taiwan. Correspondence should be sent to Dr T. H. Chen. Autogenous bone graft which has been either autoclaved or irradiated is commonly used in oriental countries as an alternative to allograft. We started to use the technique of extracorporeal irradiation of the resected specimen and reimplantation (ECIR) in 1991. There was, however, a high incidence of fracture of the irradiated bone and loss of articular cartilage. In an attempt to reduce these complications, we combined the irradiated autograft with a conventional arthroplasty. Between 1995 and 1998, 14 patients underwent limb salvage by this method. Seven had an osteosarcoma, two bony metastases, three a chondrosarcoma, one a malignant fibrous histiocytoma, and one a leiomyosarcoma. Ten tumours were located in the proximal femur, two in the proximal humerus, and two in the distal femur. One patient who had a solitary metastasis in the proximal part of the left femur died from lung metastases 13 months after operation. The remaining 13 patients were alive and without evidence of local recurrence or distant metastases at a mean follow-up of 43 months (28 to 72). Postoperative palsy of the sciatic nerve occurred in one patient, but no complications such as wound infection, fracture, or nonunion were seen. All host-irradiated bone junctions healed uneventfully within eight months. Using the Enneking functional evaluation system, the mean postoperative score for all 14 patients was 80% (57 to 93). The use of irradiated autograft prosthesis composites reduces the complications of ECIR and gives good functional results. It may be a good alternative in limb-salvage surgery, especially in countries where it is difficult to obtain allografts. This article has been cited by other articles:
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