Logo of The Journal of Bone & Joint Surgery (Br)
Quick search:        
          Advanced Search
Guest Access | Sign In
Journal of Bone and Joint Surgery - British Volume, Vol 84-B, Issue 8, 1194-1198.
doi: 10.1302/0301-620X.84B8.13187  
Copyright © 2002 by British Editorial Society of Bone and Joint Surgery
This Article
Right arrow Full Text (PDF)
Right arrow Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow My Folders
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Felländer-Tsai, L.
Right arrow Articles by Arner, P.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Felländer-Tsai, L.
Right arrow Articles by Arner, P.

In vivo physiological changes in the synovial membrane of the knee during reperfusion after arthroscopy

A STUDY USING THE MICRODIALYSIS TECHNIQUE

L. Felländer-Tsai, MD, PhD, Associate Professor and Senior Consultant Orthopaedic Surgeon1; E. Högberg, MD, Orthopaedic Resident1; T Wredmark, MD, PhD, Professor and Senior Consultant Orthpaedic Surgeon1; and P. Arner, MD, PhD, Professor and Senior Consultant in Internal Medicine2

1 Centre for Surgical Sciences, Division of Orthopaedics
2 Department of Medicine and Research Centre, Karolinska Institute at Huddinge University Hospital, SE-141 86 Stockholm, Sweden.

Correspondence should be sent to Dr L. Felländer-Tsai.

We have used in vivo microdialysis to monitor postoperative physiological events in the synovial membrane after arthroscopy. The levels of lactate were significantly higher in the synovial membrane than in the reference tissue (subcutaneous fat) and there was a significant increase in lactate after operation. Blood flow, measured as the ethanol ratio, was stable in both tissues.

Our findings show that there was an increase in the local production of lactate since the levels of lactate in blood and the reference tissue were comparable and did not show a significant increase. There was also a consumption of glucose in the synovial membrane which was not observed in the reference tissue. The levels of pyruvate were higher in the synovial membrane.

A state of reperfusion occurs in the synovial membrane after moderate trauma such as standard arthroscopy of the knee. Microdialysis should be further evaluated in studies of the in vivo physiology of the synovial membrane.






(c) British Editorial Society of Bone and Joint Surgery All Rights Reserved
Registered charity no: 209299     Print ISSN: 0301-620X
Hip, Knee, Trauma, Upper limb, Foot & Ankle, Paediatrics, Oncology, Spine, Arthroplasty, General