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Journal of Bone and Joint Surgery - British Volume, Vol 85-B, Issue 5, 753-757.
doi: 10.1302/0301-620X.85B5.13036  
Copyright © 2003 by British Editorial Society of Bone and Joint Surgery
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The origin of cells that repopulate patellar tendons used for reconstructing anterior cruciate ligaments in man

B.-H. Min, MD, PhD, Associate Professor1; M.-S. Han, PhD, Director2; J. I. Woo, MS, Student1; H.-J. Park, PhD, Associate Professor3; and S. R. Park, MD, PhD, Associate Professor of Physiology4

1 Department of Orthopaedic Surgery, Medical School of Ajou University, Suwon 442–721, Korea.
2 DNA Analysis Section, National Institute of Scientific Investigation, Sinn Weol-Dong, 7 Dong YangChun-Gu, Seoul, Korea.
3 Department of Statistics, Inha University, 253 Yonghyun-Dong, Nam-Gu, Incheon, 402–751, Korea.
4 Department of Physiology, Inha University College of Medicine, 7-241, Sinheung-Dong, Joong-Gu, Incheon 400–712, Korea.

Correspondence should be sent to Dr S. R. Park.

Cryopreserved patellar tendon allografts are often recommended for reconstruction of anterior cruciate ligaments (ACLs) because living donor fibroblasts are thought to promote repair. Animal studies, however, indicate that ligaments regenerate from recipient rather than donor cells. If applicable to man, these observations suggest that allograft cell viability is unimportant. We therefore used short tandem repeat analysis with polymerase chain reaction (PCR) amplification to determine the source of cells in nine human ACLs reconstructed with cryopreserved patellar tendon allografts. PCR amplification of donor and recipient DNA obtained before operation and DNA from the graft obtained two to ten months after transplantation revealed the genotype of cells and showed only recipient cells in the graft area. Rather than preserve the viability of donor cells, a technique is required which will facilitate the introduction of recipient cells into patellar tendon allografts.






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Hip, Knee, Trauma, Upper limb, Foot & Ankle, Paediatrics, Oncology, Spine, Arthroplasty, General