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Journal of Bone and Joint Surgery - British Volume, Vol 86-B, Issue 5, 696-700.
doi: 10.1302/0301-620X.86B5.14747  
Copyright © 2004 by British Editorial Society of Bone and Joint Surgery
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Genetic influences in the aetiology of tears of the rotator cuff

SIBLING RISK OF A FULL-THICKNESS TEAR

P. Harvie, MRCS, Girdlestone Memorial Scholar in Orthopaedic Surgery; S. J. Ostlere, FRCR, Consultant Radiologist; J. Teh, FRCR, Consultant Radiologist; E. G. McNally, FRCR, Consultant Radiologist; K. Clipsham, RGN, Research Nurse; B. J. Burston, MB, ChB, Basic Surgical Trainee, Oxford Region; T. C. B. Pollard, MB ChB, Basic Surgical Trainee, Oxford Region; and A. J. Carr, FRCS, Nuffield Professor of Orthopaedic Surgery

Nuffield Department of Orthopaedic Surgery, University of Oxford, Nuffield Orthopaedic Centre, Windmill Road, Headington, Oxford OX3 7LD, UK.

Correspondence should be sent to Professor A. J. Carr.

From a retrospective, cohort study of 205 patients diagnosed with full-thickness tears of the rotator cuff, we determined, using ultrasound, the prevalence of such tears in their 129 siblings. Using 150 spouses as controls, the relative risk of full-thickness tears in siblings versus controls was 2.42 (95% CI 1.77 to 3.31). The relative risk of symptomatic full-thickness tears in siblings versus controls was 4.65 (95% CI 2.42 to 8.63).

The significantly increased risk for tears in siblings implies that genetic factors play a major role in the development of full-thickness tears of the rotator cuff.




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Hip, Knee, Trauma, Upper limb, Foot & Ankle, Paediatrics, Oncology, Spine, Arthroplasty, General