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Journal of Bone and Joint Surgery - British Volume, Vol 87-B, Issue 10, 1434-1438.
doi: 10.1302/0301-620X.87B10.16226  
Copyright © 2005 by British Editorial Society of Bone and Joint Surgery
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Recombinant human vascular endothelial growth factor enhances bone healing in an experimental nonunion model

H. Eckardt, MD, PhD, Orthopaedic Surgeon1; M. Ding, MD, PhD, Research Fellow2; M. Lind, MD, DMSc, Orthopaedic Surgeon2; E. S. Hansen, MD, DMSc, Consultant Orthopaedic Surgeon2; K. S. Christensen, MD, Consultant Orthopaedic Surgeon1; and I. Hvid, MD, DMSc, Professor2

1 Department of Orthopaedic Surgery, Aalborg Hospital, Box 365, 9100 Aalborg, Denmark.
2 Department of Orthopaedic Surgery, Aarhus University Hospital, Noerrebrogade 44, 8000 Aarhus, Denmark.

Correspondence should be sent to Dr H. Eckardt; e-mail: henrikeckardt{at}mail.dk

The re-establishment of vascularity is an early event in fracture healing; upregulation of angiogenesis may therefore promote the formation of bone. We have investigated the capacity of vascular endothelial growth factor (VEGF) to stimulate the formation of bone in an experimental atrophic nonunion model.

Three groups of eight rabbits underwent a standard nonunion operation. This was followed by interfragmentary deposition of 100 µg VEGF, carrier alone or autograft.

After seven weeks, torsional failure tests and callus size confirmed that VEGF-treated osteotomies had united whereas the carrier-treated osteotomies failed to unite. The biomechanical properties of the groups treated with VEGF and autograft were identical. There was no difference in bone blood flow.

We considered that VEGF stimulated the formation of competent bone in an environment deprived of its normal vascularisation and osteoprogenitor cell supply. It could be used to enhance the healing of fractures predisposed to nonunion.




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