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Journal of Bone and Joint Surgery - British Volume, Vol 87-B, Issue 12, 1689-1693.
doi: 10.1302/0301-620X.87B12.16751  
Copyright © 2005 by British Editorial Society of Bone and Joint Surgery
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Growth kinetics and integrin expression of fibroblasts infiltrating devitalised patellar tendons are different from those of intrinsic fibroblasts

Y. Ikema, MD, Graduate Student1; H. Tohyama, MD, PhD, Associate Professor1; H. Nakamura, BS, Research Assistant2; F. Kanaya, MD, PhD, Professor and Chairman3; and K. Yasuda, MD, PhD, Professor and Chairman1

1 Department of Sports Medicine and Joint Reconstruction Surgery
2 Central Research Institute, Hokkaido University School of Medicine, Kita-15 Nishi-7, Sapporo 060-8638, Japan.
3 Department of Orthopaedic Surgery, Ryukyus University Faculty of Medicine, 207 Uehara, Hishihara, Okinawa 903-0215, Japan.

Correspondence should be sent to Dr H. Tohyama; e-mail: tohyama{at}med.hokudai.ac.jp

We compared the biological characteristics of extrinsic fibroblasts infiltrating the patellar tendon with those of normal, intrinsic fibroblasts in the normal tendon in vitro. Infiltrative fibroblasts were isolated from the patellar tendons of rabbits six weeks after an in situ freeze-thaw treatment which killed the intrinsic fibroblasts. These intrinsic cells were also isolated from the patellar tendons of rabbits which had not been so treated.

Proliferation and invasive migration into the patellar tendon was significantly slower for infiltrative fibroblasts than for normal tendon fibroblasts. Flow-cytometric analysis indicated that expression of {alpha}5ß1 integrin at the cell surface was significantly lower in infiltrative fibroblasts than in normal tendon fibroblasts. The findings suggest that cellular proliferation and invasive migration of fibroblasts into the patellar tendon after necrosis are inferior to those of the normal fibroblasts. The inferior intrinsic properties of infiltrative fibroblasts may contribute to a slow remodelling process in the grafted tendon after ligament reconstruction.




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Hip, Knee, Trauma, Upper limb, Foot & Ankle, Paediatrics, Oncology, Spine, Arthroplasty, General