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Journal of Bone and Joint Surgery - British Volume, Vol 87-B, Issue 5, 721-729.
doi: 10.1302/0301-620X.87B5.15542  
Copyright © 2005 by British Editorial Society of Bone and Joint Surgery
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Repair of large full-thickness articular cartilage defects in the rabbit

THE EFFECTS OF JOINT DISTRACTION AND AUTOLOGOUS BONE-MARROW-DERIVED MESENCHYMAL CELL TRANSPLANTATION

T. Yanai, MD, Postgraduate; T. Ishii, MD, PhD, Associate Professor; F. Chang, MD, Postgraduate; and N. Ochiai, MD, PhD, Professor and Chairman

Department of Orthopaedic Surgery, Institute of Clinical Medicine, Graduate School of Comprehensive Human Sciences, University of Tsukuba, 1-1-1 Tennodai, Tsukuba, Ibaraki 305-8575, Japan.

Correspondence should be sent to Dr T. Yanai; e-mail: yanai{at}mail1.accsnet.ne.jp

We produced large full-thickness articular cartilage defects in 33 rabbits in order to evaluate the effect of joint distraction and autologous culture-expanded bone-marrow-derived mesenchymal cell transplantation (ACBMT) at 12 weeks. After fixing the knee on a hinged external fixator, we resected the entire surface of the tibial plateau. We studied three groups: 1) with and without joint distraction; 2) with joint distraction and collagen gel, and 3) with joint distraction and ACBMT and collagen gel.

The histological scores were significantly higher in the groups with ACBMT collagen gel (p < 0.05). The area of regenerated soft tissue was smaller in the group allowed to bear weight (p < 0.05). These findings suggest that the repair of large defects of cartilage can be enhanced by joint distraction, collagen gel and ACBMT.




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I. Pountos, E. Jones, C. Tzioupis, D. McGonagle, and P. V. Giannoudis
Growing bone and cartilage: THE ROLE OF MESENCHYMAL STEM CELLS
J Bone Joint Surg Br, April 1, 2006; 88-B(4): 421 - 426.
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Hip, Knee, Trauma, Upper limb, Foot & Ankle, Paediatrics, Oncology, Spine, Arthroplasty, General