Logo of The Journal of Bone & Joint Surgery (Br)
Quick search:        
          Advanced Search
Guest Access | Sign In
Journal of Bone and Joint Surgery - British Volume, Vol 87-B, Issue 5, 730-735.
doi: 10.1302/0301-620X.87B5.14936  
Copyright © 2005 by British Editorial Society of Bone and Joint Surgery
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow FrenchSpanishGermanItalianRomanianPolishRussianCzech
Right arrow Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow My Folders
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Web of Science (3)
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Sharpe, J. R.
Right arrow Articles by Martin, R.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Sharpe, J. R.
Right arrow Articles by Martin, R.

The treatment of osteochondral lesions using a combination of autologous chondrocyte implantation and autograft

THREE-YEAR FOLLOW-UP

J. R. Sharpe, PhD, Senior Scientist; S. U. Ahmed, FRCS, Associate Specialist; J. P. Fleetcroft, FRCS, Consultant Orthopaedic Surgeon; and R. Martin, PhD, Senior Wound Repair Biologist

Blond McIndoe Centre, Queen Victoria Hospital, East Grinstead, Sussex RH19 3DZ, UK, Medway Maritime Hospital, Windmill Road, Gillingham, Kent ME7 5NY, UK, Smith & Nephew Research Centre, York Science Park, Heslington, York YO10 5DF, UK.

Correspondence should be sent to Dr J. R. Sharpe; e-mail: justin.sharpe{at}qvh.nhs.uk

In this study a combination of autologous chondrocyte implantation (ACI) and the osteochondral autograft transfer system (OATS) was used and evaluated as a treatment option for the repair of large areas of degenerative articular cartilage. We present the results at three years post-operatively. Osteochondral cores were used to restore the contour of articular cartilage in 13 patients with large lesions of the lateral femoral condyle (n = 5), medial femoral condyle (n = 7) and patella (n = 1). Autologous cultured chondrocytes were injected underneath a periosteal patch covering the cores. After one year, the patients had a significant improvement in their symptoms and after three years this level of improvement was maintained in ten of the 13 patients. Arthroscopic examination revealed that the osteochondral cores became well integrated with the surrounding cartilage. We conclude that the hybrid ACI/OATS technique provides a promising surgical approach for the treatment of patients with large degenerative osteochondral defects.




This article has been cited by other articles:


Home page
 J Bone Joint Surg BrHome page
S. P. Krishnan, J. A. Skinner, W. Bartlett, R. W. J. Carrington, A. M. Flanagan, T. W. R. Briggs, and G. Bentley
Who is the ideal candidate for autologous chondrocyte implantation?
J Bone Joint Surg Br, January 1, 2006; 88-B(1): 61 - 64.
[Abstract] [Full Text] [PDF]


(c) British Editorial Society of Bone and Joint Surgery All Rights Reserved
Registered charity no: 209299     Print ISSN: 0301-620X
Hip, Knee, Trauma, Upper limb, Foot & Ankle, Paediatrics, Oncology, Spine, Arthroplasty, General