Logo of The Journal of Bone & Joint Surgery (Br)
Quick search:        
          Advanced Search
Guest Access | Sign In
Journal of Bone and Joint Surgery - British Volume, Vol 87-B, Issue 8, 1157-1163.
doi: 10.1302/0301-620X.87B8.15446  
Copyright © 2005 by British Editorial Society of Bone and Joint Surgery
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow FrenchSpanishGermanItalianRomanianPolishRussianCzech
Right arrow Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow My Folders
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via Web of Science (1)
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Peter, B.
Right arrow Articles by Pioletti, D. P.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Peter, B.
Right arrow Articles by Pioletti, D. P.

The effect of bisphosphonates and titanium particles on osteoblasts

AN IN VITRO STUDY

B. Peter, PhD, Research Assistant1; P.-Y. Zambelli, MD, Orthopaedic Surgeon2; J. Guicheux, PhD, Senior Scientist, Team Leader3; and D. P. Pioletti, PhD, Senior Scientist, Team Leader1

1 Hôpital Orthopédique de la, Suisse Romande, Avenue Pierre Decker 4, 1005 Lausanne, Switzerland.
2 INSERM EMI 9903, School of Dental Surgery, 1 Place Alexis Ricordeau, 44042 Nantes Cedex 1, France.
3 Laboratory of Orthopaedic Research, Swiss Federal Institute of Technology, Bâtiment AAB, Station 15, 1015 Lausanne, Switzerland.

Correspondence should be sent to Dr D. P. Pioletti; e-mail: dominique.pioletti{at}epfl.ch

In an attempt to increase the life of cementless prostheses, an hydroxyapatite-coated implant which releases a bisphosphonate has been suggested as a drug-delivery system. Our in vitro study was designed to determine the maximum dose to which osteoblasts could be safely exposed.

Our findings demonstrated that zoledronate did not impair the proliferation of human osteoblasts when used at concentrations below 1 µM. Murine cells can be exposed to concentrations as high as 10 µM.

A concentration of 0.01% of titanium particles did not impair the proliferation of either cell line. Zoledronate affected the alkaline phosphatase activity of murine osteoblasts through a chelation phenomenon. The presence of titanium particles strongly decreased the alkaline phosphatase activity of murine osteoblasts. We did not detect any synergic effect of zoledronate and titanium particles on the behaviour of both human and murine osteoblasts.






(c) British Editorial Society of Bone and Joint Surgery All Rights Reserved
Registered charity no: 209299     Print ISSN: 0301-620X
Hip, Knee, Trauma, Upper limb, Foot & Ankle, Paediatrics, Oncology, Spine, Arthroplasty, General