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Journal of Bone and Joint Surgery - British Volume, Vol 87-B, Issue 9, 1278-1284.
doi: 10.1302/0301-620X.87B9.15583  
Copyright © 2005 by British Editorial Society of Bone and Joint Surgery
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The role of sex hormones in the kinetics of chondrocytes in the growth plate

A STUDY IN THE RABBIT

T. Irie, MD, Orthopaedic Surgeon1; T. Aizawa, MD, PhD, Orthopaedic Surgeon, Assistant Professor1; and S. Kokubun, MD, PhD, Orthopaedic Surgeon, Professor & Chairman1

1 Department of Orthopaedic Surgery, Tohoku University, School of Medicine, 1-1 Seiryo-machi, Aoba-ku, Sendai 980-8574, Japan.

Correspondence should be sent to Dr T. Aizawa; e-mail: toshi-7{at}ra2.so-net.ne.jp

Sex hormones play important roles in the regulation of the proliferation, maturation and death of chondrocytes in the epiphyseal growth plate. We have investigated the effects of male castration on the cell kinetics of chondrocytes as defined by the numbers of proliferating and dying cells. The growth plates of normal rabbits and animals castrated at eight weeks of age were obtained at 10, 15, 20 and 25 weeks of age.

Our study suggested that castration led to an increase in apoptosis and a decrease in the proliferation of chondrocytes in the growth plate. In addition, the number of chondrocytes in the castrated rabbits was less than that of normal animals of the same age.






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Hip, Knee, Trauma, Upper limb, Foot & Ankle, Paediatrics, Oncology, Spine, Arthroplasty, General