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Journal of Bone and Joint Surgery - British Volume, Vol 87-B, Issue 9, 1292-1297.
doi: 10.1302/0301-620X.87B9.15955  
Copyright © 2005 by British Editorial Society of Bone and Joint Surgery
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The effect of recombinant human osteogenic protein-1 on allograft incorporation

S. A. Lietman, MD, Assistant Professor1; N. Inoue, MD, PhD, Associate Professor2; B. Rafiee, MD, Resident2; L. W. Deitz, MD, Resident2; and E. Y. S. Chao, PhD, Professor2

1 Department of Orthopaedic Surgery, The Cleveland Clinic Foundation, 9500 Euclid Avenue, Cleveland, Ohio 44195, USA.
2 Department of Orthopaedic Surgery, John Hopkins University School of Medicine, 720 Rutland Avenue, Baltimore, Maryland 21212, USA.

Correspondence should be sent to Dr S. A. Lietman; e-mail: lietmas{at}ccf.org

We used a canine intercalary bone defect model to determine the effects of recombinant human osteogenic protein 1 (rhOP-1) on allograft incorporation. The allograft was treated with an implant made up of rhOP-1 and type I collagen or with type I collagen alone.

Radiographic analysis showed an increased volume of periosteal callus in both test groups compared with the control group at weeks 4, 6, 8 and 10. Mechanical testing after 12 weeks revealed increased maximal torque and stiffness in the rhOP-1 treated groups compared with the control group.

These results indicate a benefit from the use of an rhOP-1 implant in the healing of bone allografts. The effect was independent of the position of the implant. There may be a beneficial clinical application for this treatment.






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Hip, Knee, Trauma, Upper limb, Foot & Ankle, Paediatrics, Oncology, Spine, Arthroplasty, General