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Journal of Bone and Joint Surgery - British Volume, Vol 88-B, Issue 2, 270-275.
doi: 10.1302/0301-620X.88B2.16328  
Copyright © 2006 by British Editorial Society of Bone and Joint Surgery
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The preparation of ciprofloxacin hydrochloride-loaded chitosan and pectin microspheres

THEIR EVALUATION IN AN ANIMAL OSTEOMYELITIS MODEL

Z. Orhan, MD, Assistant Professor of Orthopaedics1; E. Cevher, PhD, Assistant Professor of Pharmaceutics2; L. Mülazimoglu, MD, Professor of Infectious Diseases and Clinical Microbiology3; D. Gürcan, MSc Pharm, Assistant Professor of Pharmaceutics2; M. Alper, MD, Assistant Professor of Pathology4; A. Araman, PhD, Professor of Pharmaceutics2; and Y. Özsoy, PhD, Assistant Professor of Pharmaceutics2

1 Department of Orthopaedics
2 Department of Pharmaceutical Technology, Faculty of Pharmacy, Istanbul University, 34116 Universite-Istanbul, Istanbul, Turkey.
3 Department of Infectious Diseases and Clinical Microbiology School of Medicine, Marmara University, Istanbul 1883, Turkey.
4 Department of Pathology Abant Izzet Baysal University, School of Medicine, Düzce 81620, Turkey.

Correspondence should be sent to Dr Z. Orhan; e-mail: zorhan{at}excite.com

Ciprofloxacin hydrochloride-loaded microspheres were prepared by a spray-drying method using pectin and chitosan. The effects of different polymers and drug ratios were investigated.

The most appropriate carriers were selected by in vitro testing. A rat methicillin-resistant Staphylococcus aureus osteomyelitis model was used to evaluate the effects of the loaded microspheres.

The drug was released rapidly from the pectin carrier but this was more sustained in the chitosan formulation.

Chitosan microspheres loaded with ciprofloxacin hydrochloride were more effective for the treatment of osteomyelitis than equivalent intramuscular antibiotics.






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Hip, Knee, Trauma, Upper limb, Foot & Ankle, Paediatrics, Oncology, Spine, Arthroplasty, General