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Journal of Bone and Joint Surgery - British Volume, Vol 88-B, Issue 3, 396-399.
doi: 10.1302/0301-620X.88B3.16606  
Copyright © 2006 by British Editorial Society of Bone and Joint Surgery
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Multiple skeletal metastases from a giant cell tumour of the distal fibula with fatal outcome

C. I. Leichtle, MD, Orthopaedic Surgeon1; U. G. Leichtle, MD, Orthopaedic Surgeon1; V. Gärtner, MD, PhD, Pathologist, Professor2; H. Schimmel, MD, Pathologist2; J. T. Hartmann, MD, PhD, Internist, Specialist for Oncology3; and M. Rudert, MD, PhD, Orthopaedic Surgeon1

1 Orthopaedic Department, Tübingen University Hospital, Hoppe-Seyler-Str. 3, D-72076 Tübingen, Germany.
2 Institute of Pathology, Tübingen University Hospital, Liebermeisterstr. 8, D-72076 Tübingen, Germany.
3 Department of Haematology, Oncology and Immunology Tübingen University Hospital, Ottfried-Müller-Str. 10, D-72076 Tübingen, Germany.

Correspondence should be sent to Dr M. Rudert; e-mail: maximilian.rudert{at}med.uni-tuebingen.de

A giant cell tumour is a primary lesion of bone of intermediate severity. Its histogenesis is unclear. In a few cases pulmonary metastases have been described. Multiple skeletal metastases in the absence of sarcomatous change have been observed.

We present a case report of a 25-year-old woman with a recurrent giant cell tumour of the distal fibula. After a second recurrence and six years after the initial diagnosis, she rapidly developed multiple bony metastases. The outcome was fatal.






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Hip, Knee, Trauma, Upper limb, Foot & Ankle, Paediatrics, Oncology, Spine, Arthroplasty, General