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Journal of Bone and Joint Surgery - British Volume, Vol 88-B, Issue 3, 406-410.
doi: 10.1302/0301-620X.88B3.16400  
Copyright © 2006 by British Editorial Society of Bone and Joint Surgery
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Transforming growth factor-beta (TGF-ß) in acute injuries of the spinal cord

J. F. Quinlan, MCh, AFRCS I, Orthopaedic Registrar1; R. W. G. Watson, PhD, Senior Lecturer2; G. Kelly, PhD, Senior Lecturer3; P. M. Kelly, FRCS(Orth), Orthopaedic Registrar1; J. M. O’Byrne, MCh, FRCS(Orth), Consultant Orthopaedic Surgeon1; and J. M. Fitzpatrick, MCh, FRCS I, FRCS G, FRCS, Professor of Surgery1

1 School of Medicine and Medical Science, Mater Misericordiae, University Hospital, Eccles Street, Dublin 7, Republic of Ireland.
2 School of Medicine and Medical Science
3 School of Mathematical Sciences, University College Dublin, Belfield, Dublin 4, Republic of Ireland.

Correspondence should be sent to Dr R. W. G. Watson; e-mail: william.watson{at}ucd.ie

Injuries to the spinal cord may be associated with increased healing of fractures. This can be of benefit, but excessive bone growth can also cause considerable adverse effects.

We evaluated two groups of patients with fractures of the spinal column, those with neurological compromise (n = 10) and those without (n = 15), and also a control group with an isolated fracture of a long bone (n = 12). The level of transforming growth factor-beta (TGF-ß), was measured at five time points after injury (days 1, 5, 10, 42 and 84).

The peak level of 142.79 ng/ml was found at day 84 in the neurology group (p < 0.001 vs other time points). The other groups peaked at day 42 and had a decrease at day 84 after injury (p ≤ 0.001).

Our findings suggest that TGF-ß may have a role in the increased bone turnover and attendant complications seen in patients with acute injuries to the spinal cord.






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Hip, Knee, Trauma, Upper limb, Foot & Ankle, Paediatrics, Oncology, Spine, Arthroplasty, General