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Journal of Bone and Joint Surgery - British Volume, Vol 88-B, Issue 9, 1228-1231.
doi: 10.1302/0301-620X.88B9.17471  
Copyright © 2006 by British Editorial Society of Bone and Joint Surgery
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Use of freeze-dried bone allograft with platelet-derived growth factor for revision of a glenoid component

L. Peidro, MD, PhD, Orthopaedic Surgeon1; J. M. Segur, MD, PhD, Orthopaedic Surgeon1; D. Poggio, MD, Orthopaedic Surgeon1; and P. Fernandez de Retana, MD, PhD, Orthopaedic Surgeon1

1 Department of Orthopaedic Surgery, Hospital Clinic, Villarroel 170, 08036 Barcelona, Spain.

Correspondence should be sent to Dr L. Peidro; e-mail: lpeidro{at}clinic.ub.es

Glenoid replacement is technically challenging. Removal of a cemented glenoid component often results in a large osseous defect which makes the immediate introduction of a revision prosthesis almost impossible. We describe a two-stage revision procedure using a reversed shoulder prosthesis. Freeze-dried allograft with platelet-derived growth factor was used to fill the glenoid defect. Radiological incorporation of the allograft was seen and its consistency allowed the placement of a screwed glenoid component. There were no signs of new mature bone formation on histological examination.

The addition of platelet-derived growth factor to the allograft seems to contribute to an increase in incorporation and hardness, but does not promote the growth of new bone.




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Platelet-rich gel as a biomaterial inducing local immune response
Tomasz M Bielecki, et al.
J Bone Joint Surg Br Online, 23 Nov 2006 [Full text]

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Hip, Knee, Trauma, Upper limb, Foot & Ankle, Paediatrics, Oncology, Spine, Arthroplasty, General