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Journal of Bone and Joint Surgery - British Volume, Vol 88-B, Issue 9, 1245-1251.
doi: 10.1302/0301-620X.88B9.17748  
Copyright © 2006 by British Editorial Society of Bone and Joint Surgery
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The novel use of resorbable Vicryl mesh for in vivo tendon reconstruction to a metal prosthesis

C. J. Pendegrass, BSc, PhD, Research Fellow1; M. J. Oddy, MA, MSc, MRCS, Research Fellow1; S. Sundar, BSc, PhD, Student1; S. R. Cannon, FRCS, Consultant Orthopaedic Surgeon2; A. E. Goodship, BVSc, PhD, MRCVS, Professor3; and G. W. Blunn, BSc, PhD, Professor1

1 The Centre for Biomedical Engineering
2 Royal National Orthopaedic Hospital
3 Institute of Orthopaedics & Musculoskeletal Science, Brockley Hill, Stanmore, Middlesex HA7 4LP, UK.

Correspondence should be sent to Dr C. J. Pendegrass; e-mail: c.pendegrass{at}ucl.ac.uk

We examined the mechanical properties of Vicryl (polyglactin 910) mesh in vitro and assessed its use in vivo as a novel biomaterial to attach tendon to a hydroxyapatite-coated metal implant, the interface of which was augmented with autogenous bone and marrow graft. This was compared with tendon re-attachment using a compressive clamp device in an identical animal model. Two- and four-ply sleeves of Vicryl mesh tested to failure under tension reached 5.13% and 28.35% of the normal ovine patellar tendon, respectively. Four-ply sleeves supported gait in an ovine model with 67.05% weight-bearing through the operated limb at 12 weeks, without evidence of mechanical failure.

Mesh fibres were visible at six weeks but had been completely resorbed by 12 weeks, with no evidence of chronic inflammation. The tendon-implant neoenthesis was predominantly an indirect type, with tendon attached to the bone-hydroxyapatite surface by perforating collagen fibres.




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S. Sundar, C. J. Pendegrass, M. J. Oddy, and G. W. Blunn
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Hip, Knee, Trauma, Upper limb, Foot & Ankle, Paediatrics, Oncology, Spine, Arthroplasty, General