Logo of The Journal of Bone & Joint Surgery (Br)
Joint Replacement Instrumentation Limited (JRI) Ad
Quick search:        
          Advanced Search
Guest Access | Sign In
Journal of Bone and Joint Surgery - British Volume, Vol 89-B, Issue 10, 1273-1279.
doi: 10.1302/0301-620X.89B10.19022  
Copyright © 2007 by British Editorial Society of Bone and Joint Surgery
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in ISI Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow My Folders
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Giannoudis, P. V.
Right arrow Articles by Pape, H. C.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Giannoudis, P. V.
Right arrow Articles by Pape, H. C.

The genetic predisposition to adverse outcome after trauma

P. V. Giannoudis, MD, EEC(Orth), Professor1; M. van Griensven, PhD, Professor2; E. Tsiridis, PhD, FRCS, Senior Lecturer and Consultant Orthopaedic Surgeon1; and H. C. Pape, MD, Professor3

1 Department of Trauma and Orthopaedics, Clarendon Wing, Floor A, Leeds General Infirmary, Great George Street, Leeds LS1 3EX, UK.
2 Ludwing Boltsmann Institute for Experimental and Clinical Traumatology, Donaueschingenstrasse 13, A-1200 Vienna, Austria.
3 Department of Orthopaedic Surgery, University of Pittsburgh, Suite 1011, Kaufmann Medical Building, 3471 Fifth Avenue, Pittsburgh, Pennsylvania 15213–2582, USA.

Correspondence should be sent to Professor P. V. Giannoudis; e-mail: pgiannoudi{at}aol.com

Technological advances and shorter rescue times have allowed early and effective resuscitation after trauma and brought attention to the host response to injury. Trauma patients are at risk of progressive organ dysfunction from what appears to be an uncontrolled immune response. The availability of improved techniques of molecular diagnosis has allowed investigation of the role of genetic variations in the inflammatory response to post-traumatic complications and particularly to sepsis.

This review examines the current evidence for the genetic predisposition to adverse outcome after trauma. While there is evidence supporting the involvement of different polymorphic variants of genes in determining the post-traumatic course and the development of complications, larger-scale studies are needed to improve the understanding of how genetic variability influences the responses to post-traumatic complications and pharmacotherapy.






(c) British Editorial Society of Bone and Joint Surgery All Rights Reserved
Registered charity no: 209299     Print ISSN: 0301-620X
Hip, Knee, Trauma, Upper limb, Foot & Ankle, Paediatrics, Oncology, Spine, Arthroplasty, General