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Journal of Bone and Joint Surgery - British Volume, Vol 89-B, Issue 2, 155-159.
doi: 10.1302/0301-620X.89B2.17747  
Copyright © 2007 by British Editorial Society of Bone and Joint Surgery
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Celecoxib versus ibuprofen in the prevention of heterotopic ossification following total hip replacement

A PROSPECTIVE RANDOMISED TRIAL

M. Saudan, MD, Orthopaedic Surgeon1; P. Saudan, MD, Physician2; T. Perneger, PhD, Professor3; N. Riand, MD, Orthopaedic Surgeon1; A. Keller, MD, Physician4; and P. Hoffmeyer, MD, Professor1

1 Division of Orthopaedic Surgery
2 Division of Nephrology
3 Quality of Care Unit
4 Department of Radiology, University Hospitals of Geneva, Rue Micheli-du-Crest 24, CH-1211, Genèva 14, Switzerland.

Correspondence should be sent to Dr M. Saudan; e-mail: marc.saudan{at}hcuge.ch

We examined whether a selective cyclooxygenase-2 (COX-2) inhibitor (celecoxib) was as effective as a non-selective inhibitor (ibuprofen) for the prevention of heterotopic ossification following total hip replacement. A total of 250 patients were randomised to receive celecoxib (200 mg b/d) or ibuprofen (400 mg t.d.s) for ten days after surgery. Anteroposterior radiographs of the pelvis were examined for heterotopic ossification three months after surgery. Of the 250 patients, 240 were available for assessment. Heterotopic ossification was more common in the ibuprofen group (none 40.7% (50), Brooker class I 46.3% (57), classes II and III 13.0% (16)) than in the celecoxib group (none 59.0% (69), Brooker class I 35.9% (42), classes II and III 5.1% (6), p = 0.002). Celecoxib was more effective than ibuprofen in preventing heterotopic bone formation after total hip replacement.




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T. W. Axelrad, B. Steen, D. W. Lowenberg, W. R. Creevy, and T. A. Einhorn
Heterotopic ossification after the use of commercially available recombinant human bone morphogenetic proteins in four patients
J Bone Joint Surg Br, December 1, 2008; 90-B(12): 1617 - 1622.
[Abstract] [Full Text] [PDF]


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Hip, Knee, Trauma, Upper limb, Foot & Ankle, Paediatrics, Oncology, Spine, Arthroplasty, General