Logo of The Journal of Bone & Joint Surgery (Br)
Quick search:        
          Advanced Search
Guest Access | Sign In
Journal of Bone and Joint Surgery - British Volume, Vol 89-B, Issue 3, 346-348.
doi: 10.1302/0301-620X.89B3.18336  
Copyright © 2007 by British Editorial Society of Bone and Joint Surgery
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow My Folders
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Danaviah, S.
Right arrow Articles by Cassol, S.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Danaviah, S.
Right arrow Articles by Cassol, S.

Atypical mycobacterial spondylitis in HIV-negative patients identified by genotyping

S. Danaviah, MMedSc, PhD Student1; S. Govender, FRCS, MD, Professor and Head of Department2; M. L. Gordon, PhD, Lecturer3; and S. Cassol, PhD, Professor4

1 Africa Centre for Health and Population Studies.
2 Department of Orthopaedic Surgery
3 Department of Virology, Nelson R. Mandela School of Medicine, University of KwaZulu-Natal, 719 Umbilo Road, Durban, 4013, South Africa.
4 HIV-1 Immunopathology and Therapuetics Research Program, Department of Immunology, Institute of Pathology, University of Pretoria, 5, Baphela Road Pretoria, 0001, South Africa.

Correspondence should be sent to Professor S. Govender; e-mail: katia{at}ukzn.ac.za

Non-tuberculous mycobacterial infections pose a significant diagnostic and therapeutic challenge. We report two cases of such infection of the spine in HIV-negative patients who presented with deformity and neurological deficit. The histopathological features in both specimens were diagnostic of tuberculosis. The isolates were identified as Mycobacterium intracellulare and M. fortuitum by genotyping (MicroSeq 16S rDNA Full Gene assay) and as M. tuberculosis and a mycobacterium other than tuberculosis, respectively, by culture. There is a growing need for molecular diagnostic tools that can differentiate accurately between M. tuberculosis and atypical mycobacteria, especially in regions of the developing world which are experiencing an increase in non-tuberculous mycobacterial infections.






(c) British Editorial Society of Bone and Joint Surgery All Rights Reserved
Registered charity no: 209299     Print ISSN: 0301-620X
Hip, Knee, Trauma, Upper limb, Foot & Ankle, Paediatrics, Oncology, Spine, Arthroplasty, General