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Journal of Bone and Joint Surgery - British Volume, Vol 89-B, Issue 4, 425-433.
doi: 10.1302/0301-620X.89B4.18301  
Copyright © 2007 by British Editorial Society of Bone and Joint Surgery
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The anabolic and catabolic responses in bone repair

D. G. Little, FRACS(Orth), PhD, Head, Orthopaedic Research & Biotechnology, and Associate Professor, Paediatrics & Child Health1; M. Ramachandran, FRCS(Orth), Paediatric Orthopaedic Fellow1; and A. Schindeler, PhD, Senior Research Officer1

1 The Children’s Hospital at Westmead, Locked Bag 4001, Westmead, New South Wales 2145, Australia.

Correspondence should be sent to Dr D. G. Little; e-mail: DavidL3{at}chw.edu.au

The literature on fracture repair has been reviewed. The traditional concepts of delayed and nonunion have been examined in terms of the phased and balanced anabolic and catabolic responses in bone repair. The role of medical manipulation of these inter-related responses in the fracture healing have been considered.






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Hip, Knee, Trauma, Upper limb, Foot & Ankle, Paediatrics, Oncology, Spine, Arthroplasty, General