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Journal of Bone and Joint Surgery - British Volume, Vol 89-B, Issue 5, 567-573.
doi: 10.1302/0301-620X.89B5.18903  
Copyright © 2007 by British Editorial Society of Bone and Joint Surgery
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Orthopaedic metals and their potential toxicity in the arthroplasty patient

A REVIEW OF CURRENT KNOWLEDGE AND FUTURE STRATEGIES

G. M. Keegan, BSc, Research Assistant1; I. D. Learmonth, FRCSEd, FRCS, FCS(SA)Orth, Professor of Orthopaedic Surgery1; and C. P. Case, DPhil, FRCPath, Consultant Senior Lecturer in Orthopaedics with Pathology1

1 University of Bristol, Bristol Implant Research Centre, Avon Orthopaedic Centre (lower level), Southmead Hospital, Westbury-on-Trym, Bristol, BS10 5NB, UK.

Correspondence should be sent to Mr C. P. Case; e-mail: c.p.case{at}bristol.ac.uk; or Gemma.Keegan{at}bristol.ac.uk

The long-term effects of metal-on-metal arthroplasty are currently under scrutiny because of the potential biological effects of metal wear debris. This review summarises data describing the release, dissemination, uptake, biological activity, and potential toxicity of metal wear debris released from alloys currently used in modern orthopaedics. The introduction of risk assessment for the evaluation of metal alloys and their use in arthroplasty patients is discussed and this should include potential harmful effects on immunity, reproduction, the kidney, developmental toxicity, the nervous system and carcinogenesis.




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eLetters:

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Is it time to make metal ion blood levels part of annual follow-up ?
Sunil K Pai, et al.
J Bone Joint Surg Br Online, 3 Aug 2007 [Full text]
Incomplete review: important papers need to be cited
Alister J Hart, et al.
J Bone Joint Surg Br Online, 21 Aug 2007 [Full text]

(c) British Editorial Society of Bone and Joint Surgery All Rights Reserved
Registered charity no: 209299     Print ISSN: 0301-620X
Hip, Knee, Trauma, Upper limb, Foot & Ankle, Paediatrics, Oncology, Spine, Arthroplasty, General