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Journal of Bone and Joint Surgery - British Volume, Vol 89-B, Issue 5, 693-700.
doi: 10.1302/0301-620X.89B5.18450  
Copyright © 2007 by British Editorial Society of Bone and Joint Surgery
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Healing of full-thickness defects of the articular cartilage in rabbits using fibroblast growth factor-2 and a fibrin sealant

I. Ishii, MD, Orthopaedic Surgeon1; H. Mizuta, MD, PhD, Professor and Chairman1; A. Sei, MD, PhD, Lecturer1; J. Hirose, MD, PhD, Orthopaedic Surgeon1; S. Kudo, MD, PhD, Orthopaedic Surgeon1; and Y. Hiraki, PhD, Professor of Cell Biology2

1 Department of Orthopaedic and NeuromusculoskeletalSurgery, Faculty of Medical and Pharmaceutical Sciences Kumamoto University, 1-1-1 Honjo, Kumamoto 860-8556, Japan.
2 Department of Cellular Differentiation, Institute for Frontier Medical Sciences Kyoto University, 53 Shogoin-Kawahara-cho, Sakyo-ku, Kyoto 606-8507, Japan.

Correspondence should be sent to Professor Y. Hiraki; e-mail: hiraki{at}frontier.kyoto-u.ac.jp

We have investigated in vitro the release kinetics and bioactivity of fibroblast growth factor-2 (FGF-2) released from a carrier of fibrin sealant. In order to evaluate the effects of the FGF-2 delivery mechanism on the repair of articular cartilage, full-thickness cylindrical defects, 5 mm in diameter and 4 mm in depth, which were too large to undergo spontaneous repair, were created in the femoral trochlea of rabbit knees. These defects were then filled with the sealant.

Approximately 50% of the FGF-2 was released from the sealant within 24 hours while its original bioactivity was maintained. The implantation of the fibrin sealant incorporating FGF-2 successfully induced healing of the surface with hyaline cartilage and concomitant repair of the subchondral bone at eight weeks after the creation of the defect.

Our findings suggest that this delivery method for FGF-2 may be useful for promoting regenerative repair of full-thickness defects of articular cartilage in humans.




eLetters:

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Healing of full-thickness defects of the articular cartilage in rabbits
Benedict A Rogers, et al.
J Bone Joint Surg Br Online, 4 Jul 2007 [Full text]
Authors' reply:
Yuji Hiraki, et al.
J Bone Joint Surg Br Online, 22 Aug 2007 [Full text]

(c) British Editorial Society of Bone and Joint Surgery All Rights Reserved
Registered charity no: 209299     Print ISSN: 0301-620X
Hip, Knee, Trauma, Upper limb, Foot & Ankle, Paediatrics, Oncology, Spine, Arthroplasty, General