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Journal of Bone and Joint Surgery - British Volume, Vol 89-B, Issue 6, 830-835.
doi: 10.1302/0301-620X.89B6.18569  
Copyright © 2007 by British Editorial Society of Bone and Joint Surgery
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Effect of progesterone on recovery from nerve injury during leg lengthening in rats

Y. Hara, MD, PhD, Assistant1; N. Ochiai, MD, PhD, Professor1; I. Abe, MD, PhD, Assistant Professor2; H. Ichimura, FRCS, MD, PhD, Orthopaedic Surgeon3; Saijilafu, MD, Student1; and Y. Nishiura, MD, PhD, Assistant Professor1

1 Department of Orthopaedic Surgery Graduate School of Comprehensive Human Sciences, University of Tsukuba, 1-1-1 Tennoudai, Tsukuba-shi, Ibaraki 305-8575, Japan.
2 Department of Orthopaedic Surgery Ibaraki Profectural University of Health Sciences, 4669-2, Ami, Amimachi, Inashiki, Ibaraki 300-0394, Japan.
3 Department of Orthopaedic Surgery Showa General Hospital, 2-450, Tenjin, Kodaira, Tokyo, Ibaraki 187-8510, Japan.

Correspondence should be sent to Dr Y. Hara; e-mail: yukihara{at}mail1.accsnet.ne.jp

We investigated the effect of progesterone on the nerve during lengthening of the limb in rats. The sciatic nerves of rats were elongated by leg lengthening for ten days at 3 mm per day. On alternate days between the day after the operation and nerve dissection, the progesterone-treated group received subcutaneous injections of 1 mg progesterone in sesame oil and the control group received oil only. On the fifth, tenth and 17th day, the sciatic nerves were excised at the midpoint of the femur and the mRNA expression level of myelin protein P0 was analysed by quantitative real time polymerase chain reaction. On day 52 nodal length was examined by electron microscopy, followed by an examination of the compound muscle action potential (C-MAP) amplitude and the motor conduction velocity (MCV) of the tibial nerve on days 17 and 52. The P0 (a major myelin glycoprotein) mRNA expression level in the progesterone-treated group increased by 46.6% and 38.7% on days five and ten, respectively. On day 52, the nodal length in the progesterone-treated group was smaller than that in the control group, and the MCV of the progesterone-treated group had been restored to normal.

Progesterone might accelerate the restoration of demyelination caused by nerve elongation by activating myelin synthesis.






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Hip, Knee, Trauma, Upper limb, Foot & Ankle, Paediatrics, Oncology, Spine, Arthroplasty, General