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Journal of Bone and Joint Surgery - British Volume, Vol 89-B, Issue 7, 901-903.
doi: 10.1302/0301-620X.89B7.18915  
Copyright © 2007 by British Editorial Society of Bone and Joint Surgery
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Genetic influences in the aetiology of anteromedial osteoarthritis of the knee

S. M. McDonnell, MBBS, BSc, MRCS(Eng), Henry Smith Research Fellow of the Royal College of Surgeons of England1; J. Sinsheimer, PhD2; A. J. Price, DPhil, FRCS(Orth), Reader in Musculoskeletal Science & Consultant Orthopaedic Surgeon of University of Oxford1; and A. J. Carr, ChM, FRCS, Nuffield Professor of Orthopaedic Surgery1

1 University of Oxford, Nuffield Department of Orthopaedic Surgery Nuffield Orthopaedic Centre, Windmill Road, Headington, Oxford OX3 7LD, UK.
2 Department of Human Genetics, Biomathematics and Biostatistics University of California Los Angeles, 5-357C Gonda, Box 951766 Los Angeles, California 90095-1766, USA.

Correspondence should be sent to Professor A. J. Carr; e-mail: andrew.carr{at}ndos.ac.uk

We report a study of 112 patients with primary anteromedial osteoarthritis of the knee and their families. Sibling risk was determined using randomly selected single siblings. Spouses were used as controls. The presence of symptomatic osteoarthritis was determined using an Oxford knee score of ≥ 29 supported by a Kellgren and Lawrence radiological score of II or greater.

Using Fisher’s exact test we found that there was a significant increased risk of anteromedial osteoarthritis (OA) relative to the control group (p = 0.031). The recurrence risk of anteromedial OA to siblings was 3.21 (95% confidence interval 1.12 to 9.27).

These findings imply that genetic factors may play a major role in the development of anteromedial OA of the knee.




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T. C. B. Pollard, S. E. Gwilym, and A. J. Carr
The assessment of early osteoarthritis
J Bone Joint Surg Br, April 1, 2008; 90-B(4): 411 - 421.
[Abstract] [Full Text] [PDF]


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Hip, Knee, Trauma, Upper limb, Foot & Ankle, Paediatrics, Oncology, Spine, Arthroplasty, General