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Journal of Bone and Joint Surgery - British Volume, Vol 89-B, Issue 8, 1110-1114.
doi: 10.1302/0301-620X.89B8.18911  
Copyright © 2007 by British Editorial Society of Bone and Joint Surgery
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Stem cells and debrided waste

TWO ALTERNATIVE SOURCES OF CELLS FOR TRANSPLANTATION OF CARTILAGE

L. C. Biant, BSc, AFRCS Ed, Specialist Registrar1; and G. Bentley, ChM, FRCS, FMedSci, Emeritus Professor of Orthopaedic Surgery1

1 The Royal National Orthopaedic Hospital, Brockley Hill, Stanmore, Middlesex HA7 4LP, UK.

Correspondence should be sent to Ms Rosemary Dutton, Secretary to Professor Bentley; e-mail: lcbiant{at}yahoo.com

Implantation of autologous chondrocytes and matrix autologous chondrocytes are techniques of cartilage repair used in the young adult knee which require harvesting of healthy cartilage and which may cause iatrogenic damage to the joint. This study explores alternative sources of autologous cells.

Chondrocytes obtained from autologous bone-marrow-derived cells and those from the damaged cartilage within the lesion itself are shown to be viable alternatives to harvest-derived cells. A sufficient number and quality of cells were obtained by the new techniques and may be suitable for autologous chondrocyte and matrix autologous chondrocyte implantation.






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Hip, Knee, Trauma, Upper limb, Foot & Ankle, Paediatrics, Oncology, Spine, Arthroplasty, General