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Journal of Bone and Joint Surgery - British Volume, Vol 89-B, Issue 8,
1122-1129.
doi: 10.1302/0301-620X.89B8.19003 Copyright © 2007 by British Editorial Society of Bone and Joint Surgery Bone transport using hydroxyapatite loaded with bone morphogenetic protein in rabbitsK. Watanabe, MD, Research Fellow1; H. Tsuchiya, MD, PhD, Associate Professor1; K. Sakurakichi, MD, PhD, Lecturer1; and K. Tomita, MD, PhD, Professor and Chairman11 Department of Orthopaedic Surgery, Graduate School of Medical Science, Kanazawa University, 13–1 Takaramachi, Kanazawa 920–8641, Japan. Correspondence should be sent to Dr H. Tsuchiya; e-mail: tsuchi{at}med.kanazawa-u.ac.jp
The feasibility of bone transport with bone substitute and the factors which are essential for a successful bone transport are unknown. We studied six groups of 12 Japanese white rabbits. Groups A to D received cylindrical autologous bone segments and groups E and F hydroxyapatite prostheses. The periosteum was preserved in group A so that its segments had a blood supply, cells, proteins and scaffold. Group B had no blood supply. Group C had proteins and scaffold and group D had only scaffold. Group E received hydroxyapatite loaded with recombinant human bone morphogenetic protein-2 and group F had hydroxyapatite alone. Distraction osteogenesis occurred in groups A to C and E which had osteo-conductive transport segments loaded with osteo-inductive proteins. We conclude that scaffold and proteins are essential for successful bone transport, and that bone substitute can be used to regenerate bone. This article has been cited by other articles:
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