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Journal of Bone and Joint Surgery - British Volume, Vol 89-B, Issue 9, 1229-1233.
doi: 10.1302/0301-620X.89B9.19422  
Copyright © 2007 by British Editorial Society of Bone and Joint Surgery
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Ewing’s sarcoma family tumours

DIFFERENCES IN CLINICOPATHOLOGICAL CHARACTERISTICS AT PRESENTATION BETWEEN LOCALISED AND METASTATIC TUMOURS

G. Bacci, MD, Medical Oncologist1; A. Balladelli, BA, Scientific Secretariat1; C. Forni, RN, Research Nurse1; A. Longhi, MD, Medical Oncologist1; M. Serra, BSc, Biologist1; N. Fabbri, MD, Orthopaedic Surgeon1; M. Alberghini, MD, Pathologist1; S. Ferrari, MD, Medical Oncologist1; M. S. Benassi, BSc, Biologist1; and P. Picci, MD, Scientific Director1

1 Istituti Ortopedici Rizzoli, Via Pupilli 1, 40136 Bologna, Italy.

Correspondence should be sent to Dr G. Bacci; email: gaetano.bacci{at}ior.it

Despite local treatment with systemic chemotherapy in Ewing’s sarcoma family tumours (ESFT), patients with detectable metastases at presentation have a markedly worse prognosis than those with apparently localised disease. We investigated the clinical, pathological and laboratory differences in 888 patients with ESFT, 702 with localised disease and 186 with overt metastases at presentation, seen at our institution between 1983 and 2006.

Multivariate analyses showed that location in the pelvis, a high level of serum lactic dehydrogenase, the presence of fever and a short interval between the onset of symptoms and diagnosis were indicative of metastatic disease. The rate of overt metastases at presentation was 10% without these four risk factors, 22.7% with one, 31.4% with two, and 50% for those with three or four factors. We concluded that in ESFT the site, the serum level of lactic dehydrogenase, fever, and the interval between the onset of symptoms and diagnosis are indicators of tumours having a particularly aggressive metastatic behaviour.




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A. H. Krieg, M. Mani, B. M. Speth, and P. D. Stalley
Extracorporeal irradiation for pelvic reconstruction in Ewing's sarcoma
J Bone Joint Surg Br, March 1, 2009; 91-B(3): 395 - 400.
[Abstract] [Full Text] [PDF]

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Serum lactic dehydrogenase as a prognostic factor of Ewing sarcoma family tumours outcome
Charalampos P. Dokos, et al.
J Bone Joint Surg Br Online, 22 Jul 2009 [Full text]

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Hip, Knee, Trauma, Upper limb, Foot & Ankle, Paediatrics, Oncology, Spine, Arthroplasty, General