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Journal of Bone and Joint Surgery - British Volume, Vol 90-B, Issue 12, 1617-1622.
doi: 10.1302/0301-620X.90B12.20975  
Copyright © 2008 by British Editorial Society of Bone and Joint Surgery
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Heterotopic ossification after the use of commercially available recombinant human bone morphogenetic proteins in four patients

T. W. Axelrad, MD, PhD, Resident Orthopaedic Surgeon1; B. Steen, MD, Resident Orthopaedic Surgeon1; D. W. Lowenberg, MD, Professor2; W. R. Creevy, MD, Professor1; and T. A. Einhorn, MD, Professor3

1 Boston University Medical Center, 850 Harrison Avenue, Dowling 2 North, Boston, Massachusetts 02118, USA.
2 Department of Orthopaedic Surgery, California Pacific Medical Center, 2100 Webster Street Suite 117, San Francisco 94115, USA.
3 Department of Orthopaedic Surgery, Boston University Medical Center, Doctors Office Building, Suite 808, 720 Harrison Avenue, Boston, Massachusetts 02118, USA.

Correspondence should be sent to Professor T. A. Einhorn; e-mail: Thomas.Einhorn{at}bmc.org

Heterotopic ossification occurring after the use of commercially available bone morphogenetic proteins has not been widely reported. We describe four cases of heterotopic ossification in patients treated with either recombinant bone morphogenetic protein 2 or recombinant bone morphogenetic protein 7. We found that while some patients were asymptomatic, heterotopic ossification which had occurred around a joint often required operative excision with good results.




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Hip, Knee, Trauma, Upper limb, Foot & Ankle, Paediatrics, Oncology, Spine, Arthroplasty, General