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Journal of Bone and Joint Surgery - British Volume, Vol 90-B, Issue 2, 145-148.
doi: 10.1302/0301-620X.90B2.19855  
Copyright © 2008 by British Editorial Society of Bone and Joint Surgery
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The use of two-stage exchange arthroplasty with depot antibiotics in the absence of long-term antibiotic therapy in infected total hip replacement

I. Stockley, MD, FRCS, Consultant Orthopaedic Surgeon1; B. J. Mockford, MPhil, FRCS (Trauma & Orth), Cavendish Hip Fellow1; A. Hoad-Reddick, FRCS (Trauma & Orth), Consultant Orthopaedic Surgeon, Cavendish Hip Fellow2; and P. Norman, FRCPath, Consultant Microbiologist1

1 Sheffield Teaching Hospitals Trust, Herries Road, Sheffield, S5 7AU, UK.
2 Wrightington Hospital, Hall Lane, Appley Bridge, Wigan WN6 9EP, UK.

Correspondence should be sent to Mr. I. Stockley; e-mail: Ian.Stockley{at}sth.nhs.uk

We present a series of 114 patients with microbiologically-proven chronically-infected total hip replacement, treated between 1991 and 2004 by a two-stage exchange procedure with antibiotic-loaded cement, but without the use of a prolonged course of antibiotic therapy. The mean follow-up for all patients was 74 months (2 to 175) with all surviving patients having a minimum follow-up of two years. Infection was successfully eradicated in 100 patients (87.7%), a rate which is similar to that reported by others, but where prolonged adjuvant antibiotic therapy has been used. Using the technique described, a prolonged course of systemic antibiotics does not appear to be essential and the high cost of the administration of antibiotics can be avoided.




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G. S. Biring, T. Kostamo, D. S. Garbuz, B. A. Masri, and C. P. Duncan
Two-stage revision arthroplasty of the hip for infection using an interim articulated Prostalac hip spacer: A 10- TO 15-YEAR FOLLOW-UP STUDY
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J. P. Whittaker, R. E. Warren, R. S. Jones, and P. A. Gregson
Is prolonged systemic antibiotic treatment essential in two-stage revision hip replacement for chronic Gram-positive infection?
J Bone Joint Surg Br, January 1, 2009; 91-B(1): 44 - 51.
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(c) British Editorial Society of Bone and Joint Surgery All Rights Reserved
Registered charity no: 209299     Print ISSN: 0301-620X
Hip, Knee, Trauma, Upper limb, Foot & Ankle, Paediatrics, Oncology, Spine, Arthroplasty, General