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Journal of Bone and Joint Surgery - British Volume, Vol 90-B, Issue 2, 246-253.
doi: 10.1302/0301-620X.90B2.19675  
Copyright © 2008 by British Editorial Society of Bone and Joint Surgery
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Impaction grafting with a bone-graft substitute in a sheep model of revision hip replacement

M. Coathup, BSc, PhD, Lecturer1; N. Smith, PhD, Research Scientist1; C. Kingsley, BSc, MBBS, Medical Student1; T. Buckland, MEng, PhD, Head of Research1; R. Dattani, BSc(Hons), MRCS, Orthopaedic Specialist Registrar1; G. P. Ascroft, BSc, MBChB, FRCS, Senior Lecturer1; and G. Blunn, BSc, PhD, Head of the Centre for Biomedical Engineering1

1 Centre for Biomedical Engineering, Institute of Orthopaedics and Musculoskeletal Science University College London, The Royal National Orthopaedic Hospital, Brockley Hill, Stanmore, Middlesex HA7 4LP, UK.

Correspondence should be sent to Professor G. Blunn; e-mail: g.blunn{at}ucl.ac.uk

An experimental sheep model was used for impaction allografting of 12 hemiarthroplasty femoral components placed into two equal-sized groups. In group 1, a 50:50 mixture of ApaPore hydroxyapatite bone-graft substitute and allograft was used. In group 2, ApaPore and allograft were mixed in a 90:10 ratio. Both groups were killed at six months. Ground reaction force results demonstrated no significant differences (p > 0.05) between the two groups at 8, 16 and 24 weeks post-operatively, and all animals remained active. The mean bone turnover rates were significantly greater in group 1, at 0.00206 mm/day, compared to group 2 at 0.0013 mm/day (p < 0.05). The results for the area of new bone formation demonstrated no significant differences (p > 0.05) between the two groups. No significant differences were found between the two groups in thickness of the cement mantle (p > 0.05) and percentage ApaPore-bone contact (p > 0.05).

The results of this animal study demonstrated that a mixture of ApaPore allograft in a 90:10 ratio was comparable to using a 50:50 mixture.






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Hip, Knee, Trauma, Upper limb, Foot & Ankle, Paediatrics, Oncology, Spine, Arthroplasty, General