Logo of The Journal of Bone & Joint Surgery (Br)
Quick search:        
          Advanced Search
Guest Access | Sign In
Journal of Bone and Joint Surgery - British Volume, Vol 90-B, Issue 3, 364-370.
doi: 10.1302/0301-620X.90B3.19806  
Copyright © 2008 by British Editorial Society of Bone and Joint Surgery
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow FrenchSpanishGermanItalianRomanianPolishRussianCzechGreek
Right arrow Submit a response
Right arrow View responses
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow My Folders
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Kubo, T.
Right arrow Articles by Ochi, M.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Kubo, T.
Right arrow Articles by Ochi, M.

Expression of hypoxia-inducible factor-1{alpha} and its relationship to tumour angiogenesis and cell proliferation in cartilage tumours

T. Kubo, MD, PhD, Assistant Professor, Orthopaedic Surgeon1; T. Sugita, MD, PhD, Director, Orthopaedic Surgeon3; S. Shimose, MD, PhD, Assistant Professor, Orthopaedic Surgeon1; T. Matsuo, MD, PhD, Assistant Professor, Orthopaedic Surgeon1; K. Arihiro, MD, PhD, Associate Professor, Pathologist2; and M. Ochi, MD, PhD, Professor and Chairman, Orthopaedic Surgeon1

1 Department of Orthopaedic Surgery
2 Department of Anatomical Pathology, Graduate School of Biomedical Sciences, Hiroshima University, 1-2-3 Kasumi, Minami-ku, Hiroshima, 734-8551, Japan.
3 Department of Orthopaedic Surgery, Hiroshima Prefecture Hospital, 1-5-54 Ujinakanda, Minami-ku, Hiroshima, 734-8530, Japan.

Correspondence should be sent to Dr T. Kubo; e-mail: kubot{at}hiroshima-u.ac.jp

We investigated the use of hypoxia-inducible factor (HIF) proteins as prognostic markers in chondrosarcoma and the relationship of HIF to the biological characteristics of cartilage tumours. The expression of HIF-1{alpha}, HIF-2{alpha}, proliferating cell nuclear antigen (PCNA) and microvessel density (MVD) were measured immunohistochemically in 29 specimens of cartilage tumour.

There was no HIF-1{alpha} and HIF-2{alpha} staining in any of the nine benign cartilage tumours. In 20 specimens of chondrosarcoma, the rate of HIF-1{alpha} and HIF-2{alpha} expression was 40% and 25%, respectively. The tumour size (≥ 8 cm), histological grade (grade 2 and grade 3) surgical margin (marginal and intralesional) and HIF-1{alpha} expression (positive) correlated significantly with a shorter disease-free survival. There was a significant association between HIF-1{alpha} and the MVD and a strong trend towards a correlation between HIF-1{alpha} and the PCNA index or histological grade.

Our findings suggest that HIF-1{alpha} protein may be a useful objective marker in the assessment of the prognosis in chondrosarcoma, since it plays an important role in tumour angiogenesis and cell proliferation.




eLetters:

Read all eLetters

Inappropriate use of a chi-squared test and the Fisher exact test
Yu-Min Lin, et al.
J Bone Joint Surg Br Online, 20 Mar 2008 [Full text]

(c) British Editorial Society of Bone and Joint Surgery All Rights Reserved
Registered charity no: 209299     Print ISSN: 0301-620X
Hip, Knee, Trauma, Upper limb, Foot & Ankle, Paediatrics, Oncology, Spine, Arthroplasty, General