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Journal of Bone and Joint Surgery - British Volume, Vol 90-B, Issue 5, 597-604.
doi: 10.1302/0301-620X.90B5.20360  
Copyright © 2008 by British Editorial Society of Bone and Joint Surgery
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Right arrow Articles by Selmi, T. A. S.
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Autologous chondrocyte implantation in a novel alginate-agarose hydrogel

OUTCOME AT TWO YEARS

T. A. S. Selmi, PhD, Orthopaedic Surgeon1; P. Verdonk, MD, Orthopaedic Surgeon1; P. Chambat, MD, Orthopaedic Surgeon2; F. Dubrana, MD, Orthopaedic Surgeon3; J.-F. Potel, MD, Orthopaedic Surgeon4; L. Barnouin, MD, Tissue Bank Manager5; and P. Neyret, PhD, Professor1

1 Centre Livet, Centre Albert, Trillat, 8 rue de Margnolles, 69300 Lyon-Caluire, France.
2 Clinique Sainte Anne Lumiere, 68 cours Albert Thomas, 69373 Lyon, Cedex 3, France.
3 Centre Hospitalier la Cavale Blanche, Boulevard Tanguy Prigent, 28609 Brest, France.
4 Clinique Cours Dillon, 1 rue Peyrolade, 31300 Toulouse, France.
5 Tissue and Cell Bank, Tissue Bank of France, 6 rue D’Italie, 69780, Mions, France.

Correspondence should be sent to Professor P. Neyret; e-mail: philippe.neyret{at}chu-lyon.fr

Autologous chondrocyte implantation is an established method of treatment for symptomatic articular defects of cartilage. CARTIPATCH is a monolayer-expanded cartilage cell product which is combined with a novel hydrogel to improve cell phenotypic stability and ease of surgical handling. Our aim in this prospective, multicentre study on 17 patients was to investigate the clinical, radiological, arthroscopic and histological outcome at a minimum follow-up of two years after the implantation of autologous chondrocytes embedded in a three-dimensional alginate-agarose hydrogel for the treatment of chondral and osteochondral defects.

Clinically, all the patients improved significantly. Patients with lesions larger than 3 cm2 improved significantly more than those with smaller lesions. There was no correlation between the clinical outcome and the body mass index, age, duration of symptoms and location of the defects. The mean arthroscopic International Cartilage Repair Society score was 10 (5 to 12) of a maximum of 12. Predominantly hyaline cartilage was seen in eight of the 13 patients (62%) who had follow-up biopsies.

Our findings suggest that autologous chondrocyte implantation in combination with a novel hydrogel results in a significant clinical improvement at follow-up at two years, more so for larger and deeper lesions. The surgical procedure is uncomplicated, and predominantly hyaline cartilage-like repair tissue was observed in eight patients.






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Hip, Knee, Trauma, Upper limb, Foot & Ankle, Paediatrics, Oncology, Spine, Arthroplasty, General