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Journal of Bone and Joint Surgery - British Volume, Vol 90-B, Issue 7, 973-979.
doi: 10.1302/0301-620X.90B7.19692  
Copyright © 2008 by British Editorial Society of Bone and Joint Surgery
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Cytotoxic effect of drugs eluted from polymethylmethacrylate on stromal giant-cell tumour cells

AN IN VITRO STUDY

D. Gouran Savadkoohi, MD, Orthopaedic Surgeon, Associate Professor of Medical Sciences1; P. Sadeghipour, MD, Student1; H. Attarian, MD, Oncologist, Assistant Professor2; S. Sardari, PhD, Assistant Professor in Pharmaceutical Biotechnology3; A. Eslamifar, PhD, Assistant Professor in Medical Pathology4; and M. A. Shokrgozar, PhD, Associate Professor in Medical Biotechnology5

1 Department of Orthopaedic Surgery Sina Hospital, Imam Khomeini Ave, Hassan Abad Sq, Tehran, Iran.
2 Department of Oncology Taleghani General Hospital, Velenjak, Tehran, Iran.
3 Department of Biotechnology
4 Department of Clinical Research
5 National Cell Bank of Iran Pasteur Institute of Iran, 69 Pasteur Ave, Tehran, Iran.

Correspondence should be sent to Dr. M. A. Shokrgozar; e-mail: mashokrgozar{at}pasteur.ac.ir

Curettage and packing with polymethylmethacrylate cement is a routine treatment for giant-cell tumour (GCT) of bone. We performed an in vitro evaluation of the cytotoxic effect of a combination of cement and methotrexate, doxorubicin and cisplatin on primary cell cultures of stromal GCT cells obtained from five patients. Cement cylinders containing four different concentrations of each drug were prepared, and the effect of the eluted drugs was examined at three different time intervals.

We found that the cytotoxic effect of eluted drugs depended on their concentration and the time interval, with even the lowest dose of each drug demonstrating an acceptable rate of cytotoxicity. Even in low doses, cytotoxic drugs mixed with polymethylmethacrylate cement could therefore be considered as effective local adjuvant treatment for GCTs.






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Hip, Knee, Trauma, Upper limb, Foot & Ankle, Paediatrics, Oncology, Spine, Arthroplasty, General