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Journal of Bone and Joint Surgery - British Volume, Vol 91-B, Issue 5, 565-576.
doi: 10.1302/0301-620X.91B5.21832  
Copyright © 2009 by British Editorial Society of Bone and Joint Surgery
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Articular cartilage tissue engineering

TODAY’S RESEARCH, TOMORROW’S PRACTICE?

A. Getgood, MRCS, DipSEM, MPhil, Clinical Research Associate1; R. Brooks, PhD, Senior Research Associate1; L. Fortier, DVM, PhD, Associate Professor of Large Animal Surgery2; and N. Rushton, MD, FRCS, Orthopaedic Surgeon & Director1

1 Orthopaedic Research Unit The University of Cambridge Orthopaedic Research Unit, Box 180, Addenbrooke’s Hospital, Hills Road, Cambridge CB2 2QQ, UK.
2 Cornell University College of Veterinary Medicine, Vet Box 32, College of Veterinary Medicine, Cornell University, Ithaca, New York 14853, USA.

Correspondence should be sent to Mr A. Getgood; e-mail: agetgood{at}btinternet.com

Articular cartilage repair remains a challenge to surgeons and basic scientists. The field of tissue engineering allows the simultaneous use of material scaffolds, cells and signalling molecules to attempt to modulate the regenerative tissue. This review summarises the research that has been undertaken to date using this approach, with a particular emphasis on those techniques that have been introduced into clinical practice, via in vitro and preclinical studies.






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Hip, Knee, Trauma, Upper limb, Foot & Ankle, Paediatrics, Oncology, Spine, Arthroplasty, General