Logo of The Journal of Bone & Joint Surgery (Br)
Quick search:        
          Advanced Search
Guest Access | Sign In
Journal of Bone and Joint Surgery - British Volume, Vol 91-B, Issue 6, 776-783.
doi: 10.1302/0301-620X.91B6.22393  
Copyright © 2009 by British Editorial Society of Bone and Joint Surgery
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Submit a response
Right arrow View responses
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow My Folders
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Rajesparan, K.
Right arrow Articles by Field, R. E.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Rajesparan, K.
Right arrow Articles by Field, R. E.

The effect of an intravenous bolus of tranexamic acid on blood loss in total hip replacement

K. Rajesparan, BSc, MRCS, Clinical Research Fellow1; L. C. Biant, FRCS Ed(Trauma & Orth), MS, Consultant Trauma and Orthopaedic Surgeon2; M. Ahmad, MB BS, Research Fellow1; and R. E. Field, PhD, FRCS, FRCS(Orth), Consultant Trauma and Orthopaedic Surgeon1

1 The Elective Orthopaedic Centre, Dorking Road, Epsom, Surrey KT18 7EG, UK.
2 The Royal Infirmary of Edinburgh, Little France Crescent, Old Dalkeith Road, Edinburgh EH16 4SA, UK.

Correspondence should be sent to Mr K. Rajesparan; e-mail: krajesparan{at}hotmail.com

Tranexamic acid is a fibrinolytic inhibitor which reduces blood loss in total knee replacement. We examined the effect on blood loss of a standardised intravenous bolus dose of 1 g of tranexamic acid, given at the induction of anaesthesia in patients undergoing total hip replacement and tested the potential prothrombotic effect by undertaking routine venography. In all, 36 patients received 1 g of tranexamic acid, and 37 no tranexamic acid. Blood loss was measured directly per-operatively and indirectly post-operatively.

Tranexamic acid reduced the early post-operative blood loss and total blood loss (p = 0.03 and p = 0.008, respectively) but not the intraoperative blood loss. The tranexamic acid group required fewer transfusions (p = 0.03) and had no increased incidence of deep-vein thrombosis. The reduction in early post-operative blood loss was more marked in women (p = 0.05), in whom this effect was dose-related (r = –0.793).

Our study showed that the administration of a standardised pre-operative bolus of 1 g of tranexamic acid was cost-effective in reducing the blood loss and transfusion requirements after total hip replacement, especially in women.




eLetters:

Read all eLetters

Aprotinin (Trasylol) does not reduce bleeding in primary THA
J Field, et al.
J Bone Joint Surg Br Online, 13 Oct 2009 [Full text]

(c) British Editorial Society of Bone and Joint Surgery All Rights Reserved
Registered charity no: 209299     Print ISSN: 0301-620X
Hip, Knee, Trauma, Upper limb, Foot & Ankle, Paediatrics, Oncology, Spine, Arthroplasty, General